Problem 1:
Bluetooth devices such as headphones, gamepad, mouse - keep randomly disconnecting. Device losing connection for 1-5 seconds and reconnects again, for example, gamepad is connected and working, but headphones lost signal, or otherwise, but never lost connection together. After waking up, Bluetooth Services appear to be running.

Hibernation disabled.

Fast boot in BIOS is disabled.
Devices fully charged.
Distance to PC doesn’t matter, same things happening in close distance and far.

Problem 2:
After waking up PC from sleep mode, Bluetooth icon in task bar disappears, and it's not possible to connect any BT device to PC. Restarting PC brings BT alive, instead of restart, I'm opening device manager, and see under Bluetooth only one Intel(R) Wireless Bluetooth(R) and if it's have yellow explanation point, then I can see "Windows has stopped this device because it has reported problems. (Code 43)". Event viewer tells me "Event 17, BTHUSB The local Bluetooth adapter has failed in an undetermined manner and will not be used. The driver has been unloaded." After disabling device and enabling, all works just fine and under Bluetooth section in Device Manager appears all of the connected devices. Second scenario: after wake up, BT device w/o yellow explanation mark, and system requires restarting, after disabling device, which helps too.
This problem occurs every time after I put PC into sleep mode. 

These problems since day one of purchase.
WIFI works great and stable, no issues at all.

Haven't tried on another PC.

No luck:
Tried to uninstall and install drivers, also tried to reinstall v21 drivers from TP-Link
Tried different USB 9pin slot on MB

Same results in PCIEx1 and PCIEx4

Windows Troubleshooter

chkdsk /f /r /x -no errors found
sfc /scannow -did not find any integrity violations.
dism /Online /Cleanup-Image /RestoreHealth -no problems

Hello, kindly refer to the below instructions to check the connection again:
https://www.tp-link.com/support/faq/2698/

You can also refer to the below article to try some more troubleshooting:
https://community.tp-link.com/en/home/forum/topic/215446

System parameters:

All USB controllers in Device Manager's Power Management unchecked with "Allow the computer to turn off this device to save power"
Latest drivers installed 22.10.0.2
Power Plan - Ultimate Performance.
Wireless Adapter Settings - Power Saving Mode - Maximum Performance
USB settings - USB selective suspend setting - Setting: Disabled
PCI Express - Link State Power Management - Setting: Off
OS: Windows 10 Pro v.20H2
MB: Gigabyte B460M Aorus Pro (latest BIOS)